Two Molecular Proteins Link to Parkinson's Disease Found

June 27, 2017

Parkinson's Disease is linked to genetic issues, however, it is more often connected to the exposure of environmental chemicals.

The symptoms may feel on one side of the body, but gradually they affect both sides of the body. Symptoms of this disease are trembling of your arms, legs, face and jaw, stiffness, slowness of movement and damage your balance and coordination. As the disease gets worse, people with this illness often have trouble in talking, walking, or doing simple tasks. And leads to the development of depression and insomnia.

Lars Brichta, A senior research associate in Greengard's Lab, together with his team, conducted a study which involves a genetically engineering mice, which help them to capture the genetical messages which being translated as a protein in a population of cells. They track the movement of regulator genes with the help of the targeted genes located in the mouse brain. They use a new tool to distinguish the changes between normal mice and the genetically engineered mouse with Parkinson's disease.

The study leads them to the discovery of 2 molecular proteins: the SATB1 and ZDHHC2, which they consider to be the key protective factors because of their unchangeable level of proteins.

Mostly it begins at the age of 65, but it can begin at an early age. Health professional's uses the patient's medical history and conducted a neurological examination to diagnose it. The disease is more common in men than women. Sadly, there were no cures for this disease. DBS or the Deep Brain stimulation can help severe cases by surgically implanting the electrodes in the brain, which sends electrical impulses to trigger the part of the brain which is responsible for the movement of our body. Some affect the ventral tegmental area, also known as (VTA), this part may become deteriorated.

Scientists are looking for molecular changes in the brain which uses genetic sequencing to create a gene expression's variation. It is hard for them to select the changes that occur in a particular cell, they only identify those that are very important through the help of conventional profiling.

Read more at Science Times

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