Should You Take Fish Oil for Multiple Sclerosis

Source: Emax Health

Considerable research revolves around the use of fish oil for a number of health challenges. What have researchers discovered about taking fish oil for multiple sclerosis?

Fish oil is a rich source of two important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These fatty acids are found in a variety of fish, especially fatty fish such as anchovy, bluefish, salmon, tuna, herring, sardines, and trout, providing about 1 gram per 3.5 ounces of fish.

Another type of omega-3 fatty acid, called alpha-linolenic acid (ALA), is found in some plants, such as flaxseeds, walnuts, pumpkin seeds, and chia seeds. The body can convert ALA to DHA and EPA, although the conversion rate is low. For those looking for a vegetarian source of the two main omega-3s, algae provides DHA but not EPA.

Fish oil for multiple sclerosis research
At least one study found that use of fish oil and fish consumption were associated with reduced fatigue. The study consisted of a survey of 2,469 individuals with multiple sclerosis who reported on various demographic, lifestyle, clinical, and medication factors. Along with fish oil, other items that had a positive impact on fatigue included vitamin D, flaxseed oil, exercise, and moderate alcohol use.

Another significant challenge for people with multiple sclerosis is depression, which can take a devastating toll on quality of life. A recent study in BMC Psychiatry reported on lifestyle factors, depression risk, and medication among 2,459 people with MS.

Nearly 20 percent of the participants screened positive for depression. When the authors evaluated various factors for risk of depression, they found that individuals who used omega-3 supplements (especially flaxseed oil), frequently ate fish, took vitamin D supplements, practiced meditation, and consumed a moderate amount of alcohol had a significantly reduced risk of depression.

On a more cellular level, a team of researchers looked at the benefits of omega-3 supplementation on myelin in a mouse model and in cultures. They observed that omega-3 supplementation reduced demyelination and improved cognitive and motor function as well as inhibited inflammation while promoting beneficial immune responses. These findings lead them to suggest that omega-3 fatty acids “may be clinically useful as immunomodulatory agents for demyelinating diseases” such as MS.

The efficacy of supplementation with fish oil was evaluated in 50 individuals with remitting-relapsing multiple sclerosis. One group took 4 grams of fish oil daily for 12 months, while the other group took a placebo.